Ombra Group is a biotechnology company that seeks to identify, mentor and facilitate the development of technologies, products and services for medical and biological applications. Ombrahas plans to file a Reg CF offering with the SEC and upon completion list the Company on an exchange by filing a 15c211.
1.) Fundamentals/Generals:
Marijuana is one of the most widely used drugs, after alcohol. It is derived from the cannabis sativa plants and contains several hundred of chemical compounds. The Δ9-tetrahydrocannabinol (THC) is the most psychoactive of the various forms of THC.
Traditionally, samples are screened for THC metabolites by immunoassay and confirmed using laboratory equipment such as GC-MS devices. The GC-MS, while the current standard
for THC metabolite testing, requires time consuming sample derivatization prior to analysis. LC/MS provides the same specificity and sensitivity without the need for a derivatization process. These kinds of analysis of THC based on urine, blood and hair probes.
THC analytics
Under the analytic determination of drugs the correct detection of tetrahydrocannabinol is one of the most difficult methods because of the formation of many metabolites. Cannabinoids are a class of diverse chemical compounds that act on cannabinoid receptors on cells that repress neurotransmitter release in the brain. These cannabinoids are the following compounds: Cannabidiol (CBD) is one of at least 85 active cannabinoids identified in cannabis. Cannabinol (CBN) is a weak psychoactive cannabinoid found only in trace amounts in Cannabis sativa and Cannabis indica. It is mostly a metabolite of tetrahydrocannabinol (THC). Cannabichromene (CBC) is a cannabinoid found also in the Cannabis plant. It bears structural similarity to the other natural cannabinoids, including tetrahydrocannabinol, tetrahydrocannabivarin, cannabidiol, and cannabinol, among others. CBC has two stereoisomers. Cannabigerol (CBG) is a non-psychoactive cannabinoid found in the Cannabis genus of plants. Tetrahydrocannabinol (THC), or more precisely
STRICTLY CONFIDENTIAL
its main isomer (−)-trans-Δ9-tetrahydrocannabinol is the principal psychoactive constituent (or cannabinoid) of cannabis.
THC is metabolized mainly to 11-OH-THC (Hydroxy-THC) by the body. This metabolite is still psychoactive and is further oxidized to 11-nor-9-carboxy-THC (THC-COOH). In humans and animals, more than 100 metabolites could be identified, but 11-OH-THC and THC-COOH are the dominating metabolites. The conversion from THC into THC carbon acid depends also on temperature during the analytical procedure.
